Top 6 Favorite Characters (Besides ???)
I don't think ??? counts as a real character. I think of him more as the "Hardcore Mode" version of Isaac. So he's not on the list. If he were on the list, he'd be between Samson and Eve.
Naturally, you have to play through with every character in order to unlock stuff, but hey, I can still have favorites.
6. SamsonSamson is my least favorite. His Bloody Lust ability just isn't very good. Well, I mean, it's not bad, since it does increase his attack power, sort of, I guess. But it certainly doesn't make up for his reduced HP and firing rate, which are severe drawbacks. Samson is basically a worse version of Judas: Judas starts out with the same crappy HP, but he doesn't have a penalty to his fire rate, he doesn't have to work to get his attack boost, and he even has a free Book of Belial (one of the best activated items) on top of everything else.
So Samson's pretty bad.
5. EveEve is hit-or-miss. If things go right, she's a powerhouse. Get an early Guppy's Paw, trade away all her hearts for soul hearts, and she'll be amazing. Maybe get a Razor Blade to keep her health low and pile soul hearts on top of that. If it works, if she can take advantage of the Whore of Babylon, then you're rolling. The problem is that you have to get lucky for her to work. If you get the wrong items, she ends up being underpowered instead. (The Dead Bird is nice to have, but on its own it's not worth the reduced stats compared to Isaac or Cain.)
That being said, if she gets going, it's fairly epic.